rukovati

1. (+ instr.) to handle; to operate
   Znaš li da rukuješ ovom mašinom? — Do you know how to operate this machine?
   Pažljivo rukujte hemikalijama. — Handle the chemicals carefully.
2. (rukovati se s someone) to shake hands
   Rukovao se sa svima u kancelariji. — He shook hands with everyone in the office.
   Kod nas se muškarci obično rukuju pri upoznavanju. — Here men usually shake hands when they meet.

In the sense 'handle' it takes the instrumental: rukovati oružjem; 'shake hands' is rukovati se s nekim.