onesposobiti

1. (of a person, machine) to disable; to incapacitate; to put out of action
   Hakeri su onesposobili sajt ministarstva. — Hackers disabled the ministry's website.
   Povreda ga je onesposobila za rad. — The injury left him unable to work.

The activity someone is rendered incapable of is often introduced with za + acc.: onesposobiti za rad means "to render unable to work".