iscrpiti

1. (of a person) to exhaust; to wear out
   Dug put nas je potpuno iscrpio. — The long journey completely exhausted us.
   Bolest ga je iscrpila za nekoliko nedelja. — The illness wore him out within a few weeks.
2. (of resources, options) to exhaust; to use up
   Iscrpili smo sve mogućnosti. — We've exhausted all the options.
   Grad je iscrpio zalihe vode. — The city used up its water supplies.
3. (iscrpiti se) to wear oneself out
   Iscrpila se radeći po celu noć. — She wore herself out working all night.

The participle iscrpljen ("exhausted, worn out") is very common in speech.